Elicitation of cyclic AMP accumulation by norepinephrine in the iron-induced epileptogenic cerebral cortex of rats.

• Hattori Yukio

• Moriwaki Akiyoshi

• Yasuhara Hiromichi

• Nishida Nobuyoshi

• Hori Yasuo

抄録

A microinjection of ferric chloride solution into the left frontal cortex of rats induced epileptic discharges which were recorded by electrocorticography. In animals having such electrographic seizure activity 30 to 60 days after the injection, the accumulation of cyclic AMP elicited by norepinephrine was examined in slices from four cortical regions. The accumulation was significantly greater in the left anterior area, into which region the ferric chloride solution was injected, than in the right anterior area. There was also a tendency for greater norepinephrine-elicited accumulation of cyclic AMP to occur in the left posterior area than in the right posterior area.

収録刊行物

• Acta Medica Okayama

  Acta Medica Okayama 37 (4), 377-380, 1983-08

  Okayama University Medical School

キーワード

• rat cerebral cortex
• iron-induced epileptic discharge
• cortical slices
• cyclic AMP
• norepinephrine

詳細情報

• CRID: 1390572174500641792
• NII論文ID: 120002311368
• NII書誌ID: AA00508441
• ISSN: 0386300X
• DOI: 10.18926/amo/32391
• PubMed: 6312769
• Web Site: https://ousar.lib.okayama-u.ac.jp/32391
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • PubMed
  • CiNii Articles