薬剤耐性細胞におけるアドリアマイシンの細胞内取り込みと細胞膜電位差の相関  [in Japanese] Relationship between intracellular uptake of adriamycin and membrane potential in ADR resistant Ehrlich ascites tumor cells  [in Japanese]

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Abstract

We observed adiamycin (ADR) uptake and cellular transmembrane potential [amount of intracellular fluorescence of 3,3'- (Di-n-hexyl)- 2,2'- oxacarbocyanine iodide (NK-2280)] in ADR-resistant cells established from Ehrlich ascites tumor cells (EATC) and wild type EATC. In ADR-resistant cells, ADR uptake and the cellular transmembrane potential decreased as the degree of resistance increased. 4,4'- diisothiocyanatostilbene- 2,2'- disulfonic acid (DIDS) induced markedly decreases of ADR uptake and the cellular transmembrane potential. A good correlation was observed between ADR uptake and transmembrane potential in cultured cells.

Journal

  • 岡山大学医療技術短期大学部紀要

    岡山大学医療技術短期大学部紀要 (3), 81-85, 1993-01-31

    岡山大学医療技術短期大学部

Codes

  • NII Article ID (NAID)
    120002313508
  • NII NACSIS-CAT ID (NCID)
    AN10355371
  • Text Lang
    JPN
  • Article Type
    departmental bulletin paper
  • ISSN
    0917-4494
  • Data Source
    IR 
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