Clinical Value and Limitations of [11C]-Methionine PET for Detection and Localization of Suspected Parathyroid Adenomas

• Herrmann, Ken

• Takei, Toshiki

• Kanegae, Kakuko

• Shiga, Tohru

• Buck, Andreas K.

• Altomonte, Jennifer

• Schwaiger, Markus

• Schuster, Tibor

• Nishijima, Kenichi

• Kuge, Yuji

• Tamaki, Nagara

抄録

Purpose: The aim of this study was to assess the clinical value of [11C]methionine-PET (MET-PET) for detection and localization of parathyroid adenomas in patients without prior thyroidectomy. Methods: A retrospective analysis of patients with suspected hyperparathyroidism undergoing imaging with MET-PET was performed. Prior thyroidectomy was an exclusion criterion. 41 patients with a total of 49 MET-PET scans were included. MET-PET consisted of whole-body images obtained 15 - 20 min after injection of 430 ± 81 MBq of MET using a dedicated PET scanner. Imaging findings were validated by histology or other imaging studies and clinical follow-up on a lesion, side and location basis. Comparison of PET results to other imaging modalities including ultrasound, MIBI scintigraphy and morphological imaging (CT and/or MRI) and subgroup analysis of primary vs. secondary hyperparathyroidism was performed. Results: 23/49 PET scans revealed pathologic findings, whereas 26/49 scans were negative. Validation of PET findings for detection and localization of hyperthyroidism resulted in an overall sensitivity of MET-PET of 54%, 49% and 35% on a lesion, side and location basis, respectively. Sensitivity of MET-PET was inferior compared to ultrasonography (50% vs. 93%), MIBI scintigraphy (53% vs. 74%) and morphological imaging (52% vs. 74%). Subgroup analysis revealed higher sensitivity for MET-PET in sHPT than pHPT (62% vs. 43%; side basis). Conclusions: In patients with initial diagnosis of hyperparathyroidism and no prior thyroidectomy, the sensitivity of MET-PET for detection and localization of hyperparathyroidism is markedly lower compared to previous reports. While performance was better in sHPT, MET-PET can not be recommended for pHPT localization in this clinically relevant subcollective.

収録刊行物

• Molecular Imaging and Biology

  Molecular Imaging and Biology 11 (5), 356-363, 2009-09

  Springer New York

キーワード

• MET-PET
• MIBI scintigraphy
• Ultrasound
• Hyperparathyroidism
• Diagnosis

詳細情報

• CRID: 1050282677651722496
• NII論文ID: 120002383243
• HANDLE: 2115/43808
• ISSN: 15361632
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles