Perfectly regioselective acylation of a cardiac glycoside, digitoxin, via catalytic amplification of the intrinsic reactivity
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抄録
Organocatalytic regioselective acylation of digitoxin has been developed. This method provides the 4′′′-O-manoacylate as the sole product without the concomitant formation of diacylates. The extremely high regioselectivity was assumed to be the result from the combined effects of the high intrinsic reactivity of C(4′′′)–OH and catalyst-promoted regioselective acylation of the same hydroxy group.
収録刊行物
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- Tetrahedron Letters
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Tetrahedron Letters 51 (37), 4830-4832, 2010-09-15
Elsevier Ltd
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詳細情報 詳細情報について
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- CRID
- 1050001335688299392
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- NII論文ID
- 120002484958
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- NII書誌ID
- AA00861801
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- ISSN
- 00404039
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- HANDLE
- 2433/126735
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- CiNii Articles