Lipid outward translocation by ABC proteins

• 植田, 和光

• Kimura, Yasuhisa

• Mastuo, Michinori

• Ueda, Kazumitsu

抄録

In humans, about 50 ABC proteins play physiologically important roles. Many ABC proteins are involved in lipid outward translocation and lipid homeostasis in the body, and defects in their functions cause various diseases. However, the precise mechanisms of substrate transport remain unclear. In bacteria, several ABC proteins are involved in the transport of lipoproteins and lipopolysaccharides from the inner to outer membrane, and their functioning is a prerequisite for survival. Their functions can be divided into "flip-flop" and "projection". In this review, human ABC proteins are compared to bacterial proteins to elucidate their mechanisms.

Lipid outward translocation by ABC proteins. Edited by Wilhelm Just (Review)

収録刊行物

• FEBS letters

  FEBS letters 584 (13), 2717-2723, 2010-07-02

  Elsevier B.V.

キーワード

• ABC protein
• Transporter
• Lipid
• Flip-flop
• Cholesterol
• Membrane
• ATP-Binding Cassette Transporters/metabolism
• Animals
• Biological Transport/physiology
• Cholesterol/metabolism
• Humans
• Lipopolysaccharides/metabolism
• Lipoproteins/metabolism
• Phospholipids/metabolism
• Xenobiotics/metabolism

詳細情報

• CRID: 1050001201940128768
• NII論文ID: 120002484960
• NII書誌ID: AA00642943
• ISSN: 00145793
• HANDLE: 2433/126737
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles
  • KAKEN