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Abstract

Lipid outward translocation by ABC proteins. Edited by Wilhelm Just (Review)In humans, about 50 ABC proteins play physiologically important roles. Many ABC proteins are involved in lipid outward translocation and lipid homeostasis in the body, and defects in their functions cause various diseases. However, the precise mechanisms of substrate transport remain unclear. In bacteria, several ABC proteins are involved in the transport of lipoproteins and lipopolysaccharides from the inner to outer membrane, and their functioning is a prerequisite for survival. Their functions can be divided into "flip-flop" and "projection". In this review, human ABC proteins are compared to bacterial proteins to elucidate their mechanisms.

Journal

  • FEBS letters

    FEBS letters 584(13), 2717-2723, 2010-07-02

    Elsevier B.V.

Cited by:  1

Codes

  • NII Article ID (NAID)
    120002484960
  • NII NACSIS-CAT ID (NCID)
    AA00642943
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    0014-5793
  • Data Source
    CJPref  IR 
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