Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat mesencephalic cultures.

• 松尾, 剛明

• 赤池, 昭紀

• Kume, Toshiaki

• Takada-Takatori, Yuki

• Sawada, Hideyuki

• Akaike, Akinori

抄録

Aripiprazole, a dopamine D(2) receptor partial agonist, is used to treat schizophrenia. Although aripiprazole has been reported to protect non-dopaminergic neurons, its effect on dopaminergic neurons has yet to be investigated. In the present study, we examined whether aripiprazole protected dopaminergic neurons against glutamate-induced cytotoxicity in rat mesencephalic cultures. Pretreatment with aripiprazole protected dopaminergic neurons in a concentration-dependent manner. The neuroprotective effect was not attenuated by sulpiride, a dopamine D(2) receptor antagonist, suggesting that the effect is independent of dopamine D(2) receptors. Aripiprazole reduced intracellular dopamine content in a concentration-dependent manner. In addition, its neuroprotective effect was partially inhibited when dopamine was added. These results suggest that aripiprazole protects dopaminergic neurons against glutamate cytotoxicity partly by reducing intracellular dopamine content.

収録刊行物

• Neuroscience letters

  Neuroscience letters 481 (2), 78-81, 2010-09-06

  Elsevier Ireland Ltd

キーワード

• Aripiprazole
• Dopamine
• Glutamate cytotoxicity
• Intracellular dopamine content
• Neuroprotective effec

詳細情報

• CRID: 1050282677154618368
• NII論文ID: 120002484966
• NII書誌ID: AA00754925
• ISSN: 03043940
• HANDLE: 2433/126831
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles