In vitro regeneration of kidney from pluripotent stem cells.

• 長船, 健二

抄録

Although renal transplantation has proved a successful treatment for the patients with end-stage renal failure, the therapy is hampered by the problem of serious shortage of donor organs. Regenerative medicine using stem cells, including cell transplantation therapy, needs to be developed to solve the problem. We previously identified the multipotent progenitor cells in the embryonic mouse kidney that can give rise to several kinds of epithelial cells found in adult kidney, such as glomerular podocytes and renal tubular epithelia. Establishing the method to generate the progenitors from human pluripotent stem cells that have the capacity to indefinitely proliferate in vitro is required for the development of kidney regeneration strategy. We review the current status of the research on the differentiation of pluripotent stem cells into renal lineages and describe cues to promote this research field.

収録刊行物

• Experimental cell research

  Experimental cell research 316 (16), 2571-2577, 2010-10-01

  Elsevier Inc.

キーワード

• Kidney regeneration
• Pluripotent stem cell
• iPS cell
• ES cell
• Animal cap
• Kidney development
• Adult
• Animals
• Humans
• Kidney/physiology
• Mice
• Pluripotent Stem Cells/physiology
• Regeneration

詳細情報

• CRID: 1050282810670380160
• NII論文ID: 120002511354
• NII書誌ID: AA00641011
• ISSN: 00144827
• HANDLE: 2433/128879
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles