A neuroeconomic theory of bidirectional synaptic plasticity and addiction

• Takahashi, Taiki

Abstract

Neuronal mechanisms underlying addiction have been attracting attention in neurobiology, economics, neuropsychiatry, and neuroeconomics. This paper proposes a possible link between economic theory of addiction (Becker and Murphy, 1988) and neurobiological theory of bidirectional synaptic plasticity (Bienenstock, Cooper, Munro, 1982) based on recent findings in neuroeconomics and neurobiology of addiction. Furthermore, it is suggested that several neurobiological substrates such as cortisol (a stress hormone), NMDA and AMPA receptors/subunits and intracellular calcium in the postsynaptic neurons are critical factors determining parameters in Becker and Murphy's economic theory of addiction. Future directions in the application of the theory to studies in neuroeconomics and neuropsychiatry of addiction and its relation to stress at the molecular level are discussed.

Journal

• Medical Hypotheses

  Medical Hypotheses 75 (4), 356-358, 2010-10

  Elsevier

Keywords

• General Medicine

Details

• CRID: 1050282677654437632
• NII Article ID: 120002603318
• DOI: 10.1016/j.mehy.2010.03.029
• HANDLE: 2115/44260
• ISSN: 03069877
• Web Site: https://api.elsevier.com/content/article/PII:S0306987710001556?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0306987710001556?httpAccept=text/plain
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN