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Abstract

BACKGROUND AND PURPOSE: The purpose was to characterize (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) findings after stereotactic body radiation therapy (SBRT) for lung cancer. MATERIALS AND METHODS: This was a retrospective review of 32 FDG-PET scans from 23 patients who underwent SBRT for lung cancer and who showed no evidence of local recurrence. The FDG uptake by lesions was assessed visually using a 3-point scale (0, none or faint; 1, mild; or 2, moderate to intense), and the demarcation (ill- or well-defined) was evaluated. For semi-quantitative analysis, the maximum standardized uptake value (SUVmax) was calculated. RESULTS: Grade 2 intensity was observed in 70%, 33%, 30%, and 0% of PET scans performed <6, 6-12, 12-24, and >24 months, respectively, after SBRT; well-defined demarcation was observed in 80%, 33%, 40%, and 17%, respectively, and the respective means of the SUVmax were 4.9, 2.6, 3.0, and 2.3. The SUVmax was significantly higher for scans performed at <6 months than at 6-12 or >24 months. CONCLUSIONS: FDG uptake tended to be intense and well-defined at early times after SBRT, especially within 6 months, and was faint and ill-defined at later periods. Moderate to intense FDG uptake observed soon after SBRT does not always indicate a residual tumour.

Journal

  • Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 97(2), 200-204, 2010-11

    Elsevier Ireland

Cited by:  1

Codes

  • NII Article ID (NAID)
    120002674607
  • NII NACSIS-CAT ID (NCID)
    AA10476884
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    1879-0887
  • Data Source
    CJPref  IR 
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