Synthetic studies of salinosporamide A through the intramolecular hydroamidation of alkynes

• 竹本, 佳司

• Kobayashi, Yusuke

• Kimachi, Tetsutaro

• Yasui, Yoshizumi

• Takemoto, Yoshiji

抄録

Rhodium-catalyzed intramolecular hydroamidation of alkynes was carried out to construct the synthetic intermediates of a proteasome inhibitor, salinosporamide A. Several alkynyl formamides were synthesized and subjected to the hydroamidation reaction. Some derivatives with a methoxymethyl (MOM) or 2-methoxy-2-propyl (MOP) group near the reaction site were converted to the corresponding lactams in excellent yields.

収録刊行物

• Journal of Organometallic Chemistry

  Journal of Organometallic Chemistry 696 (1), 42-45, 2011-01

  Elsevier BV

キーワード

• Rhodium carbonyl complexes
• C–H activation
• Alkynes
• Hydroamidation
• γ-Lactams

詳細情報

• CRID: 1050282677278147712
• NII論文ID: 120002709543
• NII書誌ID: AA00704122
• ISSN: 0022328X
• HANDLE: 2433/134562
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles