Synthetic studies of salinosporamide A through the intramolecular hydroamidation of alkynes

• Kamisaki, Haruhi

• Kobayashi, Yusuke

• Kimachi, Tetsutaro

• Yasui, Yoshizumi

• Takemoto, Yoshiji

Abstract

Rhodium-catalyzed intramolecular hydroamidation of alkynes was carried out to construct the synthetic intermediates of a proteasome inhibitor, salinosporamide A. Several alkynyl formamides were synthesized and subjected to the hydroamidation reaction. Some derivatives with a methoxymethyl (MOM) or 2-methoxy-2-propyl (MOP) group near the reaction site were converted to the corresponding lactams in excellent yields.

Journal

• Journal of Organometallic Chemistry

  Journal of Organometallic Chemistry 696 (1), 42-45, 2011-01

  Elsevier BV

Keywords

• Rhodium carbonyl complexes
• C–H activation
• Alkynes
• Hydroamidation
• γ-Lactams

Details

• CRID: 1050282677278147712
• NII Article ID: 120002709543
• NII Book ID: AA00704122
• ISSN: 0022328X
• HANDLE: 2433/134562
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles