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Abstract

Human immunodeficiency virus type 1 (HIV-1) hardly replicates in Old World monkeys. Recently, a mutant HIV-1 clone, NL-DT5R, in which a small part of gag and the entire vif gene are replaced with SIVmac239-derived ones, was shown to be able to replicate in pigtail monkeys but not in rhesus monkeys (RM). In the present study, we found that a modified monkey-tropic HIV-1 (HIV-1mt), MN4-5S, acquired the ability to replicate efficiently in cynomolgus monkeys as compared with the NL-DT5R, while neither NL-DT5R nor MN4-5S replicated in RM cells. These results suggest that multiple determinants may be involved in the restriction of HIV-1 replication in macaques, depending on the species of macaques. The new HIV-1mt clone will be useful for studying molecular mechanisms by which anti-viral host factors regulate HIV-1 replication in macaques.

Journal

  • Microbes and infection / Institut Pasteur

    Microbes and infection / Institut Pasteur 13(1), 58-64, 2011-01

    Elsevier Masson SAS

Codes

  • NII Article ID (NAID)
    120002723147
  • NII NACSIS-CAT ID (NCID)
    AA11314560
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1286-4579
  • Data Source
    IR 
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