Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin.

• 上杉, 志成

• Murata, Asako

• Orihara, Tsubasa

• Shirakawa, Takashi

• Suenaga, Kiyotake

• Kigoshi, Hideo

• Uesugi, Motonari

抄録

Aurilide is a potent cytotoxic marine natural product that induces apoptosis in cultured human cells at the picomolar to nanomolar range; however, its mechanism of action has been unknown. Results of the present study showed that aurilide selectively binds to prohibitin 1 (PHB1) in the mitochondria, activating the proteolytic processing of optic atrophy 1 (OPA1) and resulting in mitochondria-induced apoptosis. The mechanism of aurilide cytotoxicity suggests that PHB1 is an apoptosis-regulating protein amenable to modulation by small molecules. Aurilide may serve as a small-molecule tool for studies of mitochondria-induced apoptosis.

収録刊行物

• Chemistry & biology

  Chemistry & biology 18 (1), 131-139, 2011-01-28

  Elsevier Ltd

詳細情報

• CRID: 1050282676671785344
• NII論文ID: 120002807468
• NII書誌ID: AA11072585
• ISSN: 10745521
• HANDLE: 2433/137219
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles
  • KAKEN