Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin.

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Abstract

Aurilide is a potent cytotoxic marine natural product that induces apoptosis in cultured human cells at the picomolar to nanomolar range; however, its mechanism of action has been unknown. Results of the present study showed that aurilide selectively binds to prohibitin 1 (PHB1) in the mitochondria, activating the proteolytic processing of optic atrophy 1 (OPA1) and resulting in mitochondria-induced apoptosis. The mechanism of aurilide cytotoxicity suggests that PHB1 is an apoptosis-regulating protein amenable to modulation by small molecules. Aurilide may serve as a small-molecule tool for studies of mitochondria-induced apoptosis.

Journal

  • Chemistry & biology

    Chemistry & biology 18(1), 131-139, 2011-01-28

    Elsevier Ltd

Codes

  • NII Article ID (NAID)
    120002807468
  • NII NACSIS-CAT ID (NCID)
    AA11072585
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1074-5521
  • Data Source
    IR 
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