The role of nuclear pore complex in tumor microenvironment and metastasis

• Funasaka Tatsuyoshi

• Wong Richard W.

• 船坂 龍善

Abstract

金沢大学フロンティアサイエンス機構

One of the main reasons for cancer mortality is caused by the highly invasive behavior of cancer cells, which often due to aggressive metastasis. Metastasis is mediated by various growth factors and cytokines, operating through numerous signaling pathways. Remarkably, all these metastatic signaling pathways must enter the nucleus through a single gatekeeper, the nuclear pore complex (NPC). NPCs are the only gateway between the cytoplasm and the nucleus. NPCs are among the largest proteinaceous assemblies in the cell and are composed of multiple copies of around 30 different proteins called nucleoporins. Here, we review what is currently known about the NPC, and its role in the mechanisms of tumor progression. We will also explore potential strategies to target metastatic pathways by manipulating the karyopherins (importins/exportins) of nucleocytoplasmic traffic through NPCs. © 2011 Springer Science+Business Media, LLC.

Journal

• Cancer and Metastasis Reviews

  Cancer and Metastasis Reviews 30 (2), 239-251, 2011-06-01

  Springer Science+Business Media, LLC

Keywords

• Beta-catenin
• EGFR
• HIF-1
• Metastasis
• microRNA
• NF kappa B
• Nuclear pore complex
• Nucleoporins
• Smad
• TGF beta
• Tumor microenvironment

Details

• CRID: 1390858374982669568
• NII Article ID: 120002851398
• NII Book ID: AA10673193
• ISSN: 01677659
• DOI: 10.24517/00039993
• Web Site: http://hdl.handle.net/2297/26611
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • CiNii Articles
  • KAKEN