Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti-allodynic effects.

• 上田, 真史

• 佐治, 英郎

• Tominaga, A

• Yoneyama, T

• Ogawa, M

• Magata, Y

• Nishimura, H

• Kuge, Y

• Saji, H

抄録

Much interest is currently being focused on the anti-nociceptive effects mediated by nicotinic acetylcholine (nACh) receptors, including their location and mechanism of action. The purpose of this study was to elucidate these issues using 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine (5IA), a nACh receptor agonist, and [(125)I]5IA.

収録刊行物

• British journal of pharmacology

  British journal of pharmacology 159 (6), 1201-1210, 2010-03

  Wiley-Blackwell

キーワード

• nicotinic acetylcholine receptor
• thalamus
• ventral posterolateral thalamic nucleus
• 5IA
• anti-allodynic effect
• neuropathic pain
• Animals
• Autoradiography
• Azetidines/pharmacokinetics
• Azetidines/pharmacology
• Azetidines/therapeutic use
• Disease Models, Animal
• Iodine Radioisotopes
• Male
• Nicotinic Agonists/pharmacokinetics
• Nicotinic Agonists/pharmacology
• Nicotinic Agonists/therapeutic use
• Pain/drug therapy
• Pain/metabolism
• Pain Threshold
• Pyridines/pharmacokinetics
• Pyridines/pharmacology
• Pyridines/therapeutic use
• Rats
• Rats, Sprague-Dawley
• Receptors, Nicotinic/biosynthesis
• Receptors, Nicotinic/physiology
• Sciatic Neuropathy/drug therapy
• Sciatic Neuropathy/metabolism
• Ventral Thalamic Nuclei/drug effects
• Ventral Thalamic Nuclei/metabolism

詳細情報

• CRID: 1050282676917474816
• NII論文ID: 120002949728
• ISSN: 14765381
• HANDLE: 2433/139438
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles