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Abstract

遺伝子挿入のないヒトiPS細胞のより簡便な樹立法の開発.京都大学プレスリリース. 2011-04-05.We report a simple method, using p53 suppression and nontransforming L-Myc, to generate human induced pluripotent stem cells (iPSCs) with episomal plasmid vectors. We generated human iPSCs from multiple donors, including two putative human leukocyte antigen (HLA)-homozygous donors who match ∼20% of the Japanese population at major HLA loci; most iPSCs are integrated transgene-free. This method may provide iPSCs suitable for autologous and allologous stem-cell therapy in the future.

Journal

  • Nature methods

    Nature methods (8), 409-412, 2011-04-03

    Nature Publishing Group

Cited by:  2

Codes

  • NII Article ID (NAID)
    120002949763
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    1548-7105
  • Data Source
    CJPref  IR 
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