A family tree of vertebrate chemokine receptors for a unified nomenclature

• Nomiyama, Hisayuki

• Osada, Naoki

• Yoshie, Osamu

• 野見山, 尚之

• 長田, 直樹

• 義江, 修

抄録

type:論文

Chemokines receptors are involved in the recruitment of various cell types in inflammatory and physiological conditions. There are 23 known chemokine receptor genes in the human genome. However, it is still unclear how many chemokine receptors exist in the genomes of various vertebrate species other than human and mouse. Moreover, the orthologous relationships are often obscure between the genes of higher and lower vertebrates. In order to provide a basis for a unified nomenclature system of the vertebrate chemokine receptor gene family, we have analyzed the chemokine receptor genes from the genomes of 16 vertebrate species, and classify them into 29 orthologous groups using phylogenetic and comparative genomic analyses. The results reveal a continuous gene birth and death process during the vertebrate evolution and an interesting evolutionary history of the chemokine receptor genes after the emergence in agnathans.

source:0145-305X

identifier:http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T5X-5236RB7-2&_user=4545557&_coverDate=07%2F31%2F2011&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000008298&_version=1&_urlVersion=0&_userid=4545557&md5=97b2ef64f611e6b3299ea40707325a09&searchtype=a

収録刊行物

• Developmental and Comparative Immunology

  Developmental and Comparative Immunology 35 (7), 705-715, 2011-02-02

  Elsevier

キーワード

• Chemokine receptors
• Gene cluster
• Evolution
• Gene duplication
• Vertebrates
• 491

詳細情報

• CRID: 1050845762858703616
• NII論文ID: 120003039872
• Web Site: http://hdl.handle.net/2298/19000
• 本文言語コード: en
• 資料種別: article
• データソース種別:
  • IRDB
  • CiNii Articles