Repeatability of Rest and Hyperemic Myocardial Blood Flow Measurements with 82Rb Dynamic PET

• Manabe, Osamu

• Yoshinaga, Keiichiro

• Katoh, Chietsugu

• Naya, Masanao

• deKemp, Robert A.

• Tamaki, Nagara

Abstract

The repeatability of rest and hyperemic myocardial blood flow (MBF) measurements using 82Rb PET has not been evaluated. The aimof this study was to investigate the short-term repeatability of such measurements. Methods: Fifteen healthy volunteers underwent rest and pharmacologic stress 82Rb PET, repeated 60 min apart. Results: There was no significant difference in repeated rest MBF (0.77 6 0.25 vs. 0.82 6 0.25 mL/min/g, P 5 0.31; mean difference, 6.18% 6 12.22%) or repeated hyperemic MBF (3.35 6 1.37 vs. 3.39 6 1.37 mL/min/g, P 5 0.81; mean difference, 1.17% 6 13.64%). The repeatability coefficients were 0.19 mL/min/g for rest MBF and 0.92 mL/min/g for hyperemia. Conclusion:MBF using 82Rb is highly reproducible using a sameday short-term repeatability protocol. Serial MBF measurements with 82Rb PET should have the ability to quantify the acute effects of therapeutic interventions on MBF.

Journal

• Journal of Nuclear Medicine

  Journal of Nuclear Medicine 50 (1), 68-71, 2009

  Society of Nuclear Medicine

Keywords

• myocardial blood flow
• pharmacologic stress
• 82Rb

Details

• CRID: 1050564288961815808
• NII Article ID: 120003118182
• HANDLE: 2115/46752
• ISSN: 01615505
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles