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Abstract

【Purpose】To investigate the progression of vascular lesions of polypoidal choroidal vasculopathy (PCV) as viewed with indocyanine green angiography and the visual prognosis of these eyes. 【Design】Retrospective case study. 【Methods】We reviewed retrospectively the medical records of 88 consecutive patients (88 eyes) with PCV who had been examined with indocyanine green angiography for more than 2 years. 【Results】Depending on the initial area of the vascular lesion, eyes were divided into smaller PCV (baseline area of lesion being < 1 disc area [DA], n = 22) and larger PCV (baseline area of lesion being ≥ 1 DA, n = 66). In larger PCV, the mean area of the lesion progressed significantly from 6.49 ± 8.96 mm2 to 16.27 ± 14.19 mm2 (P < .0001) with marked deterioration of visual acuity (P < .0001) during follow-up. In contrast, smaller PCV often showed minimal progression of the lesion, only limited exudative change, and the eyes maintained their initially good vision to the final visit. Smaller PCV lesions rarely progressed to extensive PCV lesions. Severe vision-threatening complications (ie, suprachoroidal hemorrhage, vitreous hemorrhage, and tears of the retinal pigment epithelium) were seen only in eyes with larger PCV, and in studying single nucleotide polymorphisms A69S of ARMS2 genes, there was a significant difference in T allele frequency between individuals with smaller PCV and those with larger PCV (20.2% vs 79.8%; P = .0235). 【Conclusions】PCV with small vascular lesions shows minimal progression and no vision-threatening complications, and these eyes often maintain good visual acuity for a long time.

Journal

  • American journal of ophthalmology

    American journal of ophthalmology 151(6), 961-972.e1, 2011-06

    Elsevier Inc.

Cited by:  1

  • Polypoidal Choroidal Vasculopathy  [in Japanese]

    YUZAWA Mitsuko , 川村 昭之 , 中静 裕之 , 森 隆三郎 , 田中 公二 , 春山 美穂 , 島田 宏之 , 藤田 京子 , 赤座 英里子 , 服部 隆幸 , 水谷 吉宏 , 北川 貴子 , 清水 早穂 , 大平 香寿美 , 山本 篤志 , 三俣 昌子 , 中山 智祥 , 沖坂 重邦 , 石橋 達朗 , 飯島 裕幸 , 飯田 知弘 , 大路 正人 , 白神 史雄 , 高橋 寛二 , 竹田 宗泰 , 張野 正誉 , 吉村 長久 , 小椋 祐一郎

    日本眼科學会雜誌 116(3), 200-232, 2012-03-10

    Ichushi Web  References (111) Cited by (3)

Codes

  • NII Article ID (NAID)
    120003184066
  • NII NACSIS-CAT ID (NCID)
    AA11523017
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    0002-9394
  • Data Source
    CJPref  IR 
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