Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis

• 太田, 智子

• 太田, 和俊

• 城野, 博史

• 藤森, 裕巳

• 植田, 光晴

• 神力, 悟

• 末吉, 貴直

• 篠原, 正徳

• 安東, 由喜雄

• Ota, Tomoko

• Ota, Kazutoshi

• Jono, Hirofumi

• Fujimori, Hiromi

• Shinriki, Satoru

• Sueyoshi, Takanao

• Shinohara, Masanori

抄録

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論文(Article)

The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy. We performed immunohistochemistry to examine MK expression in specimens of adenoid cystic carcinoma (ACC), mucoepidermoid carcinoma (MEC), and pleomorphic adenoma (PA). In addition, we performed immunohistochemistry for CD31 and measured microvessel density (MVD), which is an indicator of angiogenesis. Immunohistochemistry showed that MK protein expression was significantly higher in specimens of malignant SGTs (ACC [P < 0.01] and MEC [P < 0.001]) than in benign SGT (PA) samples. Furthermore, MVD values tended to be higher in cases that exhibited high expression of MK, which indicated a significant correlation between the degree of MK expression and MVD (P < 0.001). These results suggest that MK may play important roles in malignant transformation and tumor angiogenesis in SGTs.

http://www.sciencedirect.com/science/article/pii/S1368837510001879

収録刊行物

• Oral Oncology

  Oral Oncology 46 (9), 657-661, 2010-09

  Elsevier

キーワード

• Midkine
• Head and neck cancer
• Salivary gland tumor
• Adenoid cystic carcinoma
• Mucoepidermoid carcinoma
• Pleomorphic adenoma
• Pathologic angiogenesis
• CD31antigen
• Immunohistochemistry

詳細情報

• CRID: 1050282812905392000
• NII論文ID: 120003184564
• HANDLE: 2298/20239
• Web Site: https://kumadai.repo.nii.ac.jp/records/24912
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles
  • KAKEN