Access this Article

Search this Article

Abstract

小胞体カウンターイオンチャネルTRICチャネルによる血圧調節機構とTRICチャネル遺伝子多型による本態性高血圧リスク. 京都大学プレスリリース. 2011-08-02.

TRIC channel subtypes, namely TRIC-A and TRIC-B, are intracellular monovalent cation channels postulated to mediate counter-ion movements facilitating physiological Ca(2+) release from internal stores. Tric-a-knockout mice developed hypertension during the daytime due to enhanced myogenic tone in resistance arteries. There are two Ca(2+) release mechanisms in vascular smooth muscle cells (VSMCs); incidental opening of ryanodine receptors (RyRs) generates local Ca(2+) sparks to induce hyperpolarization, while agonist-induced activation of inositol trisphosphate receptors (IP(3)Rs) evokes global Ca(2+) transients causing contraction. Tric-a gene ablation inhibited RyR-mediated hyperpolarization signaling to stimulate voltage-dependent Ca(2+) influx, and adversely enhanced IP(3)R-mediated Ca(2+) transients by overloading Ca(2+) stores in VSMCs. Moreover, association analysis identified single-nucleotide polymorphisms (SNPs) around the human TRIC-A gene that increase hypertension risk and restrict the efficiency of antihypertensive drugs. Therefore, TRIC-A channels contribute to maintaining blood pressure, while TRIC-A SNPs could provide biomarkers for constitutional diagnosis and personalized medical treatment of essential hypertension.

Journal

  • Cell metabolism

    Cell metabolism 14(2), 231-241, 2011-08-03

    Elsevier

Cited by:  2

  • Hunting for genes for hypertension : the Millennium Genome Project for Hypertension

    TABARA Yasuharu , KOHARA Katsuhiko , MIKI Tetsuro , FUJIOKA Akihiro , HANADA Hironori , HATA Akira , HIRAWA Nobuhito , HIURA Yumiko , IMAI Yutaka , INOKO Hidetoshi , INOUE Itsuro , ITOH Norihiko , IWAI Naoharu , KULSKI Jerzy K. , KAMIDE Kei , KATO Norihiro , KATSUYA Tomohiro , KAWAMOTO Ryuichi , KAWANO Yuhei , KIMURA Akinori , KITA Yoshikuni , KOKUBO Yoshihiro , MANO Hiroyuki , MANO Shuhei , MIYATA Toshiyuki , MIZUKI Nobuhisa , MORISAKI Takayuki , NAKAMURA Yasuyuki , NAKAO Kazuwa , NAKAYAMA Tomohiro , NAKURA Jun , OGAWA Momoko , OGIHARA Toshio , OHKUBO Takayoshi , OHNO Shigeaki , OKA Akira , OKAMURA Tomonori , SARUTA Takao , SEKINE Akihiro , SHIWA Tadashi , SOMA Masayoshi , SUGANO Sumio , TAJIMA Atsushi , TAKAHASHI Norio , TAKASHIMA Naoyuki , TAKEUCHI Fumihiko , TOKUNAGA Katsushi , TOMOIKE Hitonobu , UESHIMA Hirotsugu , UMEMURA Satoshi , YAMANE Takahiro , YANAI Kazuyuki , YASUNAMI Michio , YATSU Keisuke , YOSHIDA Teruhiko

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 35(6), 567-573, 2012-06-01

    Ichushi Web  References (31)

  • Current treatment of hypertension  [in Japanese]

    RAKUGI Hiromi

    Nihon Naika Gakkai Zasshi 101(3), 619-624, 2012-03-10

    J-STAGE  Ichushi Web  References (17)

Codes

  • NII Article ID (NAID)
    120003255678
  • NII NACSIS-CAT ID (NCID)
    AA11978571
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    1932-7420
  • Data Source
    CJPref  IR 
Page Top