Age Differences in the Relation Between ACTN3 R577X Polymorphism and Thigh-Muscle Cross-Sectional Area in Women

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Abstract

The relation between ACTN3 R577X polymorphism and muscle mass in women has been reported, but its relation to age remains unclear. We investigated the relationship between ACTN3 R577X polymorphism and muscle mass in both middle-aged and elderly women. Two age groups (middle-aged and older) were formed among 162 healthy, nontraining Japanese women (mean±SE, 58.6±0.8 year). Their midthigh-muscle cross-sectional area (CSA) was assessed using magnetic resonance imaging, revealing no difference in thigh-muscle CSA among ACTN3 R577X genotypes in the middle-aged group (XX, 87.3±2.5 cm2; RR&RX, 86.1±1.7 cm2, p=0.7). In contrast, the XX genotype in the older group had a smaller thigh-muscle CSA adjusted to body weight than the RR&RX genotypes (XX, 67.8±2.0 cm2; RR&RX, 72.5±1.2 cm2, p<0.05). The present study showed an association between ACTN3 R577X polymorphism and smaller thigh-muscle CSA in a group of elderly women but not in a group of middle-aged women.

Journal

  • Genetic testing and molecular biomarkers

    Genetic testing and molecular biomarkers 15(9), 639-643, 2011-09

    Mary Ann Liebert

Codes

  • NII Article ID (NAID)
    120003386770
  • NII NACSIS-CAT ID (NCID)
    AA1238373X
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1945-0265
  • Data Source
    IR 
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