Bisphenol-A suppresses neurite extension due to inhibition of phosphorylation of mitogen-activated protein kinase in PC12 cells

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Abstract

An endocrine disrupter, bisphenol-A is widely used in the production of plastics and coatings. Recently, it was reported that bisphenol-A affected neurotransmitters in the mammalian brain. On the basis of these reports, it was considered that bisphenol-A affected neuronal differentiation. In this study, the morphological changes in nerve growth factor (NFG)-induced differentiation caused by bisphenol-A were confirmed using a PC12 cell system. When a low concentration of bisphenol-A was added to medium containing NGF, it inhibited neurite extension. In addition, to clarify whether bisphenol-A affects the early and late stages of the NGF-signaling pathway in cell differentiation, changes of phosphorylation of MAP kinases and cAMP-response element binding protein (CREB) in PC12 cells treated with and without BPA in medium containing NGF were investigated using western blot analysis. As results, bisphenol-A significantly inhibited phosphorylation of CREB and ERK1/2 MAPK.

Journal

  • Chemico-Biological Interactions

    Chemico-Biological Interactions 194(1), 23-30, 2011-10-15

    Elsevier Ireland

Codes

  • NII Article ID (NAID)
    120003483496
  • NII NACSIS-CAT ID (NCID)
    AA0060252X
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0009-2797
  • Data Source
    IR 
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