Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells.

• 柳田, 敦子

• Iwaisako, Keiko

• Hatano, Etsuro

• Taura, Kojiro

• Sato, Fumiaki

• Narita, Masato

• Nagata, Hiromitsu

• Asechi, Hiroyuki

• Uemoto, Shinji

• Kinoshita, Makoto

抄録

Sept4, a subunit of the septin cytoskeleton specifically expressed in quiescent hepatic stellate cells (HSCs), is downregulated through transdifferentiation to fibrogenic and contractile myofibroblastic cells. Since Sept4(-/-)mice are prone to liver fibrosis, we aimed to identify the unknown molecular network underlying liver fibrosis by probing the association between loss of Sept4 and accelerated transdifferentiation of HSCs.

収録刊行物

• Biochimica et biophysica acta

  Biochimica et biophysica acta 1812 (11), 1403-1411, 2011-11

  Elsevier B.V.

キーワード

• Septin
• Hepatic stellate cell
• Canonical Wnt pathway
• Dkk (Dickkopf)
• Myofibroblastic transformation
• Liver fibrosis

詳細情報

• CRID: 1050001335723590656
• NII論文ID: 120003517932
• NII書誌ID: AA00564635
• ISSN: 00063002
• HANDLE: 2433/149268
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles