Efficacy of pre-operative chemotherapy with docetaxel, cisplatin, and S-1 (DCS therapy) and curative resection for gastric cancer with pathologically positive para-aortic lymph nodes

• Oyama, Katsunobu

• Fushida, Sachio

• Kinoshita, Jun

• Makino, Isamu

• Nakamura, Keishi

• Hayashi, Hironori

• Nakagawara, Hisatoshi

• Tajima, Hidehiro

• Fujita, Hideto

• Takamura, Hiroyuki

• Ninomiya, Itasu

• Kitagawa, Hirohisa

• Tani, Takashi

• Fujimura, Takashi

• Ohta, Tetsuo

抄録

Background: The prognosis of gastric cancer with para-aortic lymph node (PAN) metastasis is poor. We applied triple combination chemotherapy with docetaxel, cisplatin, and S-1 (DCS therapy) as pre-operative chemotherapy and investigated the outcome of the combination of this therapy and gastrectomy with para-aortic lymph node dissection (PAND). Methods: We retrospectively identified 44 patients with pathologically positive PAN who underwent curative surgery at Kanazawa University Hospital between 1990 and 2008. Among the 44 patients, 16 received pre-operative DCS therapy and subsequent surgical resection after two courses of the therapy. Results: Pre-operative DCS therapy showed high clinical response ratio (68.8%) and disease control ratio (100%). The pathological response ratio of resected specimen was 87.5%. At 2 years after surgery, the overall survival ratio was 93.8% and relapse-free survival was 75.0%. Pre-operative DCS therapy was only independent prognostic factor in multivariate analysis. Grade 3/4 toxicity was observed only in 25.0% of patients who underwent DCS therapy. Surgical complication was observed in 31.3% of patients, and this ratio was equal to that of patients who did not receive DCS therapy. Conclusion: Multimodal therapy comprising combined pre-operative DCS therapy and gastrectomy with PAND was extremely effective and feasible for advanced gastric cancer with PAN metastasis. J. Surg. Oncol © 2011 Wiley Periodicals, Inc.

収録刊行物

• Journal of Surgical Oncology

  Journal of Surgical Oncology 105 (6), 535-541, 2012-05-01

  Wiley-Blackwell

キーワード

• Gastric cancer
• Para-aortic lymph node dissection
• Para-aortic lymph node metastasis
• Pre-operative chemotherapy

詳細情報

• CRID: 1050845760880966528
• NII論文ID: 120003534660
• NII書誌ID: AA00708010
• ISSN: 00224790
• Web Site: http://hdl.handle.net/2297/29561
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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  • CiNii Articles