Treatment of tetracycline antibiotics by laccase in the presence of 1-hydroxybenzotriazole

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Abstract

Tetracycline antibiotics are widely used in human and veterinary medicine; however, residual amounts of these antibiotics in the environment are of concern since they could contribute to selection of resistant bacteria. In this study, tetracycline (TC), chlortetracycline (CTC), doxycycline (DC) and oxytetracycline (OTC) were treated with laccase from the white rot fungus Trametes versicolor in the presence of the redox mediator 1-hydroxybenzotriazole (HBT). High performance liquid chromatography demonstrated that DC and CTC were completely eliminated after 15min, while TC and CTC were eliminated after 1h. This system also resulted in a complete loss of inhibition of growth of Escherichia coli and Bacillus subtilis and the green alga Pseudokirchneriella subcapitata with decreasing tetracycline antibiotic concentration. These results suggest that the laccase-HBT system is effective in eliminating tetracycline antibiotics and removing their ecotoxicity.

Journal

  • Bioresource technology

    Bioresource technology 103(1), 498-501, 2011-10-20

    Elsevier

Codes

  • NII Article ID (NAID)
    120003535063
  • NII NACSIS-CAT ID (NCID)
    AA11522750
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0960-8524
  • Data Source
    IR 
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