Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET : comparison with 15O-labelled water PET

• Yoshinaga, Keiichiro

• Manabe, Osamu

• Katoh, Chietsugu

• Chen, Li

• Klein, Ran

• Naya, Masanao

• deKemp, Robert A.

• Williams, Kathryn

• Beanlands, Rob S. B.

• Tamaki, Nagara

Abstract

Purpose: Endothelial dysfunction is the earliest abnormality in the development of coronary atherosclerosis. Rubidium-82 (82Rb) is a generator-produced positron emission tomography (PET) myocardial perfusion tracer that is becoming more widely used. We aimed to develop a method for quantitative assessment of coronary endothelial function using the myocardial blood flow (MBF) response during a cold pressor test (CPT) in smokers, measured using 82Rb PET and ii) compare the results with those measured using 15O-water PET. Methods: MBF was assessed at rest and during CPT with 82Rb and 15O-water in 9 controls and 10 smokers. A one-compartment model with tracer extraction correction was used to estimate MBF with both tracers. CPT response was calculated as the ratio of MBF during CPT to MBF at rest. Results: At rest, measurements of MBF for smokers vs. controls were not different using 15O-water (0.86 ± 0.18 vs. 0.70 ± 0.13, p = 0.426) than they were using 82Rb (0.83 ± 0.23 vs. 0.62 ± 0.20, p = 0.051). Both methods showed a reduced CPT response in smokers vs. controls (15O-water, 1.03 ± 0.21 vs. 1.42 ± 0.29, p = 0.006; 82Rb, 1.02 ± 0.28 vs. 1.70 ± 0.52, p < 0.001). There was high reliability [intra-class correlation coefficients: 0.48 (0.07, 0.75)] of MBF measurement between 82Rb and 15O-water during CPT. Conclusions: Using CPT, 82Rb MBF measurements detected coronary endothelial dysfunctions in smokers. 82Rb MBF measurements were comparable to those made using the 15O-water approach. Thus, 82Rb PET may be applicable for risk assessments or evaluation of risk factor modification in subjects with coronary risk factors.

Journal

• European Journal of Nuclear Medicine and Molecular Imaging

  European Journal of Nuclear Medicine and Molecular Imaging 37 (12), 2233-2241, 2010-12

  Springer Berlin / Heidelberg

Keywords

• Blood flow
• Endothelium
• Positron emission tomography
• Smoking

Details

• CRID: 1050845763937226368
• NII Article ID: 120003537873
• HANDLE: 2115/47526
• ISSN: 16197070
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles