Para-Aortic Lymph Node Micrometastasis in Patients with Node-Negative Biliary Cancer

• Yonemori, Atsuya

• Kondo, Satoshi

• Matsuno, Yoshihiro

• Ito, Tomoo

• Tanaka, Eiichi

• Hirano, Satoshi

抄録

Background/Aims: The presence of para-aortic lymph node metastasis in biliary cancer negatively impacts prognosis. The present study aims to immunohistochemically identify and evaluate the clinical significance of para-aortic lymph node micrometastases in 66 patients who had undergone curative resection of biliary cancer. Methods: We used an antibody against cytokeratins 7 and 8 (CAM5.2) to immunostain 529 para-aortic lymph nodes that were negative according to conventional analysis from 66 patients with biliary cancer. Results: We detected CAM5.2-positive occult carcinoma cells in para-aortic lymph nodes from 3 (5%) of the 66 patients and in 3 (0.6%) of the 529 para-aortic lymph nodes. One of the three patients also had micrometastasis in the regional lymph nodes. All three patients with para-aortic lymph node micrometastasis are alive at 45, 48 and 90 months after surgery despite having locally advanced cancer. Conclusions: Occult cancer cells were identified in para-aortic lymph nodes from 5% of patients with node-negative biliary cancer, yet these patients have survived over the long term. The presence of para-aortic nodal micrometastasis might not have influence on survival. However, further studies including a greater number of patients are required to support this notion.

収録刊行物

• Digestive Surgery

  Digestive Surgery 28 (4), 315-321, 2011-10

  Karger

キーワード

• Para-aortic lymph node
• Micrometastasis
• Isolated tumor cells
• Biliary cancer

詳細情報

• CRID: 1050845763939652352
• NII論文ID: 120003560576
• HANDLE: 2115/47664
• ISSN: 02534886
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles