An Epstein-Barr Virus-Associated Leukemic Lymphoma in a Patient Treated with Rabbit Antithymocyte Globulin and Cyclosporine for Hepatitis-Associated Aplastic Anemia

• Ohata, Kinya

• Iwaki, Noriko

• Kotani, Takeharu

• Kondo, Yukio

• Yamazaki, Hirohito

• Nakao, Shinji

Abstract

Lymphoproliferative disorders (LPDs) are generally caused by uncontrolled B-cell proliferation induced by the Epstein-Barr virus (EBV) in the setting of impaired EBV-specific T-cell immunity, particularly when there is pharmacological immunosuppression including antithymocyte globulin. We herein present an unusual case of EBV associated with LPD (EBV-LPD) in which LPD occurred 3 weeks after the use of rabbit antithymocyte globulin administered for severe hepatitis-associated aplastic anemia; the patient died of fulminant leukemic lymphoma 5 days after the onset. We also review the pertinent literature on EBV-LPD after immunosuppressive therapy and document the efficacy of EBV viral load monitoring and the need for preemptive therapy. Copyright © 2011 S. Karger AG, Basel.

Journal

• Acta Haematologica

  Acta Haematologica 127 (2), 96-99, 2011-12-15

  karger

Details

• CRID: 1050845760880984320
• NII Article ID: 120003752533
• NII Book ID: AA0050796X
• ISSN: 00015792
• Web Site: http://hdl.handle.net/2297/30117
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles