Nucleocytoplasmic shuttling of cytoskeletal proteins: molecular mechanism and biological significance.
抄録
Various nuclear functional complexes contain cytoskeletal proteins as regulatory subunits; for example, nuclear actin participates in transcriptional complexes, and actin-related proteins are integral to chromatin remodeling complexes. Nuclear complexes such as these are involved in both basal and adaptive nuclear functions. In addition to nuclear import via classical nuclear transport pathways or passive diffusion, some large cytoskeletal proteins spontaneously migrate into the nucleus in a karyopherin-independent manner. The balance of nucleocytoplasmic distribution of such proteins can be altered by several factors, such as import versus export, or capture and release by complexes. The resulting accumulation or depletion of the nuclear populations thereby enhances or attenuates their nuclear functions. We propose that such molecular dynamics constitute a form of cytoskeleton-modulated regulation of nuclear functions which is mediated by the translocation of cytoskeletal components in and out of the nucleus.
収録刊行物
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- International journal of cell biology
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International journal of cell biology 2012 1-12, 2012
Hindawi Publishing Corporation
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詳細情報 詳細情報について
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- CRID
- 1050845760656525440
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- NII論文ID
- 120003824935
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- ISSN
- 16878876
- 16878884
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- HANDLE
- 2433/153017
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- Crossref
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