Efficient synthesis of aminomethylated azaindoles and corresponding pyrrole-fused derivatives by copper-catalyzed domino multicomponent coupling and cyclization

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Abstract

Efficient methods for the synthesis of aminomethylated azaindole derivatives via domino copper-catalyzed multicomponent coupling and cyclization have been developed. Using various secondary amines and aldehydes, N-substituted 3-ethynyl-4-aminopyridine was converted to substituted azaindoles in moderate to excellent yields. By use of a 3, 4-diaminopyridine derivative bearing two alkynyl groups, the corresponding pyrrole-fused azaindoles were synthesized by controlled stepwise cyclization.

Journal

  • Tetrahedron

    Tetrahedron 68(6), 1695-1703, 2012-02

    Elsevier Ltd.

Codes

  • NII Article ID (NAID)
    120003874274
  • NII NACSIS-CAT ID (NCID)
    AA11539786
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0040-4020
  • Data Source
    IR 
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