Thin films of single-walled carbon nanotubes promote human osteoblastic cells (Saos-2) proliferation in low serum concentrations

• Akasaka, Tsukasa

• Yokoyama, Atsuro

• Matsuoka, Makoto

• Hashimoto, Takeshi

• Watari, Fumio

抄録

One strategy used for the regeneration of bone is the development of cell culture substrates and scaffolds that can control osteoblast proliferation and differentiation. In recent investigations, carbon nanotubes (CNTs) have been utilized as scaffolds for osteoblastic cell cultures; however, there are only a few reports describing the proliferation of osteoblastic cells on thin CNT films; in particular, the effects of serum concentration on cell proliferation has not been studied. In the present study, we prepared culture dishes with homogeneous thin or thick films of non-modified CNTs and examined the effect of serum concentrations on human osteoblastic cells (Saos-2) proliferation in these culture dishes. We demonstrated that the ratio of cell proliferation was strongly affected by the concentration of serum. Interestingly, single-walled carbon nanotube (SWNT) thin films were found to be the most effective substrate for the proliferation of Saos-2 cells in low concentrations of serum. Thus, thin SWNT films may be used as an effective biomaterial for the culture of Saos-2 cells in low serum concentrations.

収録刊行物

• Materials Science and Engineering: C

  Materials Science and Engineering: C 30 (3), 391-399, 2010-04

  Elsevier

キーワード

• Carbon nanotubes
• Thin film
• Cell proliferation
• Serum
• Osteoblastic cells
• Protein adsorption

詳細情報

• CRID: 1050282813987305088
• NII論文ID: 120003878528
• NII書誌ID: AA11397783
• HANDLE: 2115/48563
• ISSN: 09284931
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles