Successful treatment of Trichosporon fungemia in a patient with refractory acute myeloid leukemia using voriconazole combined with liposomal amphotericin B

• Hosokawa, Kohei

• Yamazaki, Hiroto

• Mochizuki, K.

• Ohata, K.

• Ishiyama, K.

• Hayashi, Tomoe

• Kondo, Y.

• Sugimori, Naomi

• Okumura, H.

• Takami, Akiyoshi

• Nakao, Shinji

Abstract

Trichosporon fungemia is a rare and fatal fungal infection that occurs in patients with prolonged neutropenia associated with hematologic malignancies. A 21-year-old male developed Trichosporon fungemia during remission induction therapy for acute myeloid leukemia (AML). Although two courses of induction therapy failed to induce a remission of AML, combination therapy with voriconazole and liposomal amphotericin B (L-AmB) followed by monocyte colony-stimulating factor ameliorated the Trichosporon fungemia and enabled the patient to receive reduced-intensity bone marrow transplantation (BMT) from his human leukocyte antigen-A one-locus mismatched mother. The patient achieved a durable remission after BMT without exacerbation of Trichosporon fungemia. The combination therapy with voriconazole and L-AmB may therefore be useful in controlling Trichosporon fungemia associated with prolonged neutropenia after remission induction therapy for AML.

Journal

• Transplant Infectious Disease

  Transplant Infectious Disease 14 (2), 184-187, 2012-04-01

  John Wiley & Sons A/S

Keywords

• Trichosporon fungemia
• voriconazole
• L-AmB
• combination therapy
• M-CSF
• acute myeloid leukemia

Details

• CRID: 1050845760914011392
• NII Article ID: 120003989036
• NII Book ID: AA11369686
• ISSN: 13982273
• Web Site: http://hdl.handle.net/2297/30362
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles