Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes.

Access this Article

Search this Article

Abstract

Epigenetic modifications that govern the gene expression are often overlooked with the design of artificial genetic switches. N-Methylpyrrole-N-methylimidazole (PI) hairpin polyamides are programmable small DNA binding molecules that have been studied in the context of gene regulation. Recently, we synthesized a library of compounds by conjugating PI polyamides with SAHA, a chromatin-modifier. Among these novel compounds, PI polyamide-SAHA conjugate 1 was shown to epigenetically activate pluripotency genes in mouse embryonic fibroblasts. Here, we report the synthesis of the derivatives of conjugate 1 and demonstrate that these epigenetically active molecules could be developed to improve the induction of pluripotency factors.

Journal

  • Bioorganic & medicinal chemistry

    Bioorganic & medicinal chemistry 20(8), 2656-2660, 2012-04-15

Codes

  • NII Article ID (NAID)
    120004025596
  • NII NACSIS-CAT ID (NCID)
    AA11522681
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0968-0896
  • Data Source
    IR 
Page Top