Stealth-nanoparticle strategy for enhancing the efficacy of steroids in mice with noise-induced hearing loss.

• Horie, Rie T

• Sakamoto, Tatsunori

• 中川, 隆之

• Ishihara, Tsutomu

• Higaki, Megumu

• Ito, Juichi

抄録

This study aimed to investigate the efficacy of encapsulating steroids, which is a primary choice for the treatment of sensorineural hearing loss, in polyethylene glycol-coated polylactic acid nanoparticles for drug delivery to the cochlea.

収録刊行物

• Nanomedicine

  Nanomedicine 5 (9), 1331-1340, 2010-11

  Future Medicine Ltd.

キーワード

• Drug delivery
• Glucocorticoid
• Hair cell
• Cochlea
• Hearing impairment
• Noise trauma
• Animals
• Betamethasone/administration & dosage
• Betamethasone/analogs & derivatives
• Betamethasone/pharmacokinetics
• Betamethasone/therapeutic use
• Cochlea/metabolism
• Hair Cells, Auditory/metabolism
• Hearing Loss, Noise-Induced/drug therapy
• Hearing Loss, Noise-Induced/metabolism
• Hearing Loss, Noise-Induced/physiopathology
• Immunohistochemistry
• Lactic Acid/chemistry
• Liver/metabolism
• Male
• Mice
• Nanoparticles/adverse effects
• Nanoparticles/chemistry
• Polyethylene Glycols/chemistry
• Polymers/chemistry
• Receptors, Glucocorticoid/metabolism
• Rhodamines/administration & dosage
• Rhodamines/metabolism
• Steroids/administration & dosage
• Steroids/pharmacokinetics
• Steroids/therapeutic use

詳細情報

• CRID: 1050001335734515200
• NII論文ID: 120004184965
• NII書誌ID: AA12157344
• ISSN: 17435889
• HANDLE: 2433/156290
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles