Sputum YKL-40 Levels and Pathophysiology of Asthma and Chronic Obstructive Pulmonary Disease.

• Otsuka, Kojiro

• 松本, 久子

• Niimi, Akio

• Muro, Shigeo

• Ito, Isao

• Takeda, Tomoshi

• Terada, Kunihiko

• Yamaguchi, Masafumi

• Matsuoka, Hirofumi

• Jinnai, Makiko

• Oguma, Tsuyoshi

• Nakaji, Hitoshi

• Inoue, Hideki

• Tajiri, Tomoko

• Iwata, Toshiyuki

• Chin, Kazuo

• Mishima, Michiaki

抄録

Background: Recent evidence suggests that YKL-40, also called chitinase-3-like-1 protein, is involved in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). Details of sputum YKL-40 in asthma and COPD, however, remain unknown. Objectives: To clarify associations of sputum YKL-40 levels with clinical indices in asthma and COPD. Methods: Thirty-nine patients with asthma, 14 age-matched never-smokers as controls, 45 patients with COPD, and 7 age-matched smokers as controls were recuited for this study. Sputum YKL-40 levels were measured and YKL-40 expression in sputum cells was evaluated by immunocytochemistry. Results: Sputum YKL-40 levels were higher in patients with COPD (346 ± 325 ng/ml) than in their smoker controls (125 ± 122 ng/ml; p < 0.05), but were not significantly different between patients with asthma (117 ± 170 ng/ml) and their controls (94 ± 44 ng/ml; p = 0.15). In patients with asthma only, sputum YKL-40 levels were positively correlated with disease severity (r = 0.34, p = 0.034) and negatively correlated with pre- and postbronchodilator %FEV(1) (r = -0.47 and -0.42, respectively; p < 0.01) and forced mid-expiratory flow (r = -0.48 and -0.46, respectively, p < 0.01). Sputum YKL-40 levels were positively correlated with sputum neutrophil counts in asthma (r = 0.55, p < 0.001) and with neutrophil and macrophage counts in COPD (r = 0.45 and 0.65, respectively, p < 0.01). YKL-40 was expressed in the cytoplasm of sputum neutrophils and macrophages in all groups. Conclusions: Elevated sputum YKL-40 reflects airflow obstruction in asthma whereas the roles of YKL-40 in the proximal airways in COPD remain to be elucidated.

収録刊行物

• Respiration; international review of thoracic diseases

  Respiration; international review of thoracic diseases 83 (6), 507-519, 2012

  Karger

詳細情報

• CRID: 1050282810711510784
• NII論文ID: 120004397864
• NII書誌ID: AA00816840
• ISSN: 00257931
• HANDLE: 2433/158368
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles