Disposition kinetics of taxanes in peritoneal dissemination

• Miyamoto Ken-ichi

• Shimada Tsutomu

• Sawamoto Kazuki

• Sai Yoshimichi

• Yonemura Yutaka

• 宮本 謙一

• 嶋田 努

• 澤本 一樹

• 崔 吉道

• 米村 豊

Abstract

Treatment of cancers in the abdominal cavity, such as peritoneal dissemination, is difficult, but in principle intraperitoneal administration of anticancer drugs is expected to be preferable to systemic administration. Taxane anticancer drugs are used to treat gastric cancer patients with peritoneal dissemination. They are administered as micellar preparations, Taxol and Taxotere, which consist of paclitaxel in Cremophor EL (crEL) and docetaxel in Polysorbate-80 (PS-80), respectively. In this paper we review the disposition kinetics of taxane anticancer drugs after intraperitoneal administration in peritoneal dissemination patients and animal models and also discuss the effect of the surfactant vehicle on the behavior of taxanes. Copyright © 2012 Ken'ichi Miyamoto et al.

Journal

• Gastroenterology Research and Practice

  Gastroenterology Research and Practice 2012 963403-, 2012-01-01

  Hindawi Publishing Corporation

Details

• CRID: 1390296808233230976
• NII Article ID: 120004419377
• DOI: 10.24517/00026782
• ISSN: 16876121
• Web Site: http://hdl.handle.net/2297/31960
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • CiNii Articles