Overview of orexin/hypocretin system

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A series of recent studies has established the orexin/hypocretin system as a critical regulator of sleep/wake states. Its deficiency results in the sleep disorder narcolepsy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy and insomnia. Moreover, accumulating evidence indicates that the orexin/hypocretin system regulates sleep and wakefulness through interactions with neuronal systems that regulate emotion, reward, and energy homeostasis. Here, we briefly summarize the progress of orexin/hypocretin studies and future perspectives. © 2012 Elsevier B.V..

収録刊行物

  • Progress in Brain Research

    Progress in Brain Research (198), 5-14, 2012-01-01

    Elsevier B.V

各種コード

  • NII論文ID(NAID)
    120004419378
  • NII書誌ID(NCID)
    AA00357710
  • 本文言語コード
    ENG
  • 資料種別
    journal article
  • ISSN
    0079-6123
  • データ提供元
    IR 
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