三叉神経一次感覚ニューロンにおける内向き整流作用のグルタミン酸受容体依存性神経修飾機構 Glutamatergic modulation of slow inward rectification in trigeminal primary sensory neurons

Access this Article

Search this Article

Abstract

In the present study, we showed that activation of metabotropic glutamate receptors in rat mesencephalic trigminal (Mes V) neurons (which are important in the genesis and control of oral-motor activities) can modulate hyperpolarization-activated inward current (Ih). Whole-cell recordings were obtained from rat Mes V neurons, and I_h was induced by a hyperpolarizing current or voltage pulses. Application of ACPD, which is a group I and II mGluRs agonist, suppressed the voltage-and time-dependent voltage sag under current-clamp recording, and suppressed the steady-state inward current under voltage-clamp recording, suggesting that it inhibited I_h. Further investigation revealed that group II mGluRs activation and the release of intracellular Ca^<2+> mediated ACPD-in-duced inhibition of I_h. Additionally, low-frequency (<10Hz) resonant properties exhibited at membrane potentials ranging from resting potential to hyperpolarization were substantially reduced by ACPD, indicating that modulation of I_h by mGluRs activation induces substantial changes in the frequency preference with which neurons respond to synaptic inputs.

Journal

  • 松本歯学

    松本歯学 34(1), 1-12, 2008-04-30

    松本歯科大学学会

Codes

  • NII Article ID (NAID)
    120004428249
  • NII NACSIS-CAT ID (NCID)
    AN00232590
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0385-1613
  • Data Source
    IR 
Page Top