Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL).

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Abstract

The clinical entity of adult T-cell leukemia (ATL) was established around 1977, and human T-cell leukemia virus type 1 (HTLV-I) was subsequently identified in 1980. In the 25 years since the discovery of HTLV-I, HTLV-I infection and its associated diseases have been extensively studied, and many of their aspects have been clarified. However, the detailed mechanism of leukemogenesis remains unsolved yet, and the prognosis of ATL patients still poor because of its resistance to chemotherapy and immunodeficiency. In this review, I highlight the recent progress and remaining enigmas in HTLV-I infection and its associated diseases, especially ATL.

Journal

  • Retrovirology

    Retrovirology (2), 2005-04-26

    BioMed Central Ltd.

Codes

  • NII Article ID (NAID)
    120004754360
  • NII NACSIS-CAT ID (NCID)
    AA12051445
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1742-4690
  • Data Source
    IR 
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