Pathophysiology of unilateral asterixis due to thalamic lesion.

• 井上, 学

• Kojima, Yasuhiro

• Mima, Tatsuya

• Sawamoto, Nobukatsu

• Matsuhashi, Masao

• Fumuro, Tomoyuki

• Kinboshi, Masato

• Koganemaru, Satoko

• Kanda, Masutarou

• Shibasaki, Hiroshi

抄録

[Objective]:Unilateral asterixis has been reported in patients with thalamic lesion. This study aims at elucidating the pathophysiology of the thalamic asterixis. [Methods]:Two cases with unilateral asterixis caused by an infarction in the lateral thalamus were studied by analysing the asterixis-related cortical activities, transcranial magnetic stimulation (TMS) for motor cortex excitability and probabilistic diffusion tractography for the thalamo-cortical connectivity. [Results]:Averaging of electroencephalogram (EEG) time-locked to the asterixis revealed rhythmic oscillations of a beta band at the central area contralateral to the affected hand. TMS revealed a decrease in the motor evoked potential (MEP) amplitude and a prolongation of the silent period (SP). The anatomical mapping of connections between the thalamus and cortical areas using a diffusion-weighted image (DWI) showed that the lateral thalamus involved by the infarction was connected to the premotor cortex, the primary motor cortex (M1) and the primary somatosensory cortex (S1) of the corresponding hemisphere. [Conclusions]:The thalamic asterixis is mediated by the sensorimotor cortex, which is subjected to excessive inhibition as a result of the thalamic lesion involving the ventral lateral nucleus. [Significance]:This is the first demonstration of participation of the sensorimotor cortex in the generation of asterixis due to the lateral thalamic lesion.

収録刊行物

• Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 123 (9), 1858-1864, 2012-09

  Elsevier Ireland Ltd.

キーワード

• Thalamic asterixis
• Thalamic infarction
• Asterixis-related cortical activity
• Motor cortex excitability
• Thalamo-cortical connectivity
• Aged
• Brain Injuries/complications
• Brain Mapping
• Cerebral Cortex/pathology
• Cerebral Cortex/physiopathology
• Diffusion Magnetic Resonance Imaging
• Dyskinesias/diagnosis
• Dyskinesias/etiology
• Electric Stimulation
• Electroencephalography
• Electromyography
• Evoked Potentials, Motor/physiology
• Functional Laterality/physiology
• Humans
• Magnetic Resonance Imaging
• Male
• Neural Pathways/pathology
• Reaction Time
• Thalamus/pathology
• Transcranial Magnetic Stimulation

詳細情報

• CRID: 1050282810716488064
• NII論文ID: 120004873783
• NII書誌ID: AA11309888
• ISSN: 13882457
• HANDLE: 2433/160142
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles