Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone
Access this Article
Search this Article
Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O7-modified glaziovianin A showed strong cytotoxicity against HeLa S3 cells. Compared to glaziovianin A, the O7-benzyl and O7-propargyl analogues were more cytotoxic against HeLa S3 cells and more potent M-phase inhibitors. Furthermore, O7-modified molecular probes of glaziovianin A were synthesized for biological studies.
- Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry 20(19), 5745-5756, 2012-10