Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone

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Abstract

Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O7-modified glaziovianin A showed strong cytotoxicity against HeLa S3 cells. Compared to glaziovianin A, the O7-benzyl and O7-propargyl analogues were more cytotoxic against HeLa S3 cells and more potent M-phase inhibitors. Furthermore, O7-modified molecular probes of glaziovianin A were synthesized for biological studies.

Journal

  • Bioorganic & medicinal chemistry

    Bioorganic & medicinal chemistry 20(19), 5745-5756, 2012-10

    Elsevier

Keywords

Codes

  • NII Article ID (NAID)
    120004921505
  • NII NACSIS-CAT ID (NCID)
    AA10938083
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0968-0896
  • Data Source
    IR 
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