Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocoupling

• Nagaki, Aiichiro

• Uesugi, Yuki

• Tomida, Yutaka

• Yoshida, Jun-ichi

Abstract

The use of FeCl3 resulted in a fast homocoupling of aryllithiums, and this enabled its integration with the halogen–lithium exchange reaction of aryl halides in a flow microreactor. This system allows the homocoupling of two aryl halides bearing electrophilic functional groups, such as CN and NO2, in under a minute.

Journal

• BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

  BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 7 1064-1069, 2011-08

  Beilstein-Institut

Keywords

• homocoupling
• iron salts
• microreactor
• organolithiums

Details

• CRID: 1050845760675303168
• NII Article ID: 120004996582
• ISSN: 18605397
• HANDLE: 2433/163437
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles