Development of a dual functional luminescent sensor for zinc ion based on a peptidic architecture.
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A synthetic peptide bearing a lanthanide complex, TbOTZ exhibits a decrease of chromophore fluorescence and a concomitant luminescence enhancement due to sensitized Tb(3+) upon Zn(2+) binding. Thus, TbOTZ can be a valuable tool for ratiometric sensing of Zn(2+) as well as for time-resolved fluorescence detection with a single molecule.
- Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters 22(24), 7410-7413, 2012-12-15