A Simulation Study of the Radiation-Induced Bystander Effect : Modeling with Stochastically Defined Signal Reemission

• Sasaki, Kohei

• Wakui, Kosuke

• Tsutsumi, Kaori

• Itoh, Akio

• Date, Hiroyuki

Abstract

The radiation-induced bystander effect (RIBE) has been experimentally observed for different types of radiation, cell types, and cell culture conditions. However, the behavior of signal transmission between unirradiated and irradiated cells is not well known. In this study, we have developed a new model for RIBE based on the diffusion of soluble factors in cell cultures using a Monte Carlo technique. The model involves the signal emission probability from bystander cells following Poisson statistics. Simulations with this model show that the spatial configuration of the bystander cells agrees well with that of corresponding experiments, where the optimal emission probability is estimated through a large number of simulation runs. It was suggested that the most likely probability falls within 0.63-0.92 for mean number of the emission signals ranging from 1.0 to 2.5.

Journal

• Computational and Mathematical Methods in Medicine

  Computational and Mathematical Methods in Medicine 2012 389095-, 2012

  Hindawi Publishing Corporation

Keywords

• Applied Mathematics
• General Immunology and Microbiology
• General Biochemistry, Genetics and Molecular Biology
• Modeling and Simulation
• General Medicine

Details

• CRID: 1050845763942328192
• NII Article ID: 120005108190
• DOI: 10.1155/2012/389095
• ISSN: 17486718
• ISSN: 1748670X
• HANDLE: 2115/51068
• Web Site: http://downloads.hindawi.com/journals/cmmm/2012/389095.pdf
• Web Site: http://downloads.hindawi.com/journals/cmmm/2012/389095.xml
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN