尿管皮膚瘻によって治癒しえたCyclophosphamide低用量長期内服による出血性膀胱炎の1例

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タイトル別名
  • Long-Term Oral Low-Dose Cyclophosphamide-Induced Hemorragic Cystitis which was Successfully Treated by Ureterostomy : A Case Report
  • ニョウカン ヒフロウ ニ ヨッテ チユ シエタ Cyclophosphamide テイヨウリョウ チョウキ ナイフク ニ ヨル シュッケツセイ ボウコウエン ノ 1レイ

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An 80-year-old man presented to our hospital with macroscopic hematuria. Before coming to our hospital, he was treated for multiple myeloma with cyclophosphamide. We detected diffuse dilation of capillary on urinary bladder mucosa on cystoscopy, and diagnosed the patient with cyclophosphamide-induced hemorrhagic cystitis. Macroscopic hematuria once resolved by indwelling urethral catheter, but recurred and bladder tamponade developed. We performed transurethral electric coagulation. Macroscopic hematuria temporarily disappeared, but again relapsed. Then we performed intravesical instillation of aluminum hydroxide gel, but without a clear effect and the patient developed hemorrhagic shock. Eventually, we performed bilateral ureterostomy because the disease was unresponsive to less invasive therapies. Vesical bleeding disappeared and the patient was discharged 32 days after surgery. The treatment for multiple myeloma has been continued without cyclophosphamide since surgery.

収録刊行物

  • 泌尿器科紀要

    泌尿器科紀要 58 (12), 687-690, 2012-12

    泌尿器科紀要刊行会

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