Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4).

• Oishi, Shinya

• Fujii, Nobutaka

Abstract

The development of novel peptide and peptidomimetic ligands for the CXC chemokine receptor 4 (CXCR4) as therapeutic agents for HIV-1 infection, cancer, and immune system diseases has grown over the last decade. In this perspective article, the design of CXCR4 agonists and antagonists from endogenous stromal cell-derived factor-1 (SDF-1)/CXCL12 and horseshoe crab-derived antimicrobial peptides and their therapeutic and diagnostic applications are described.

Journal

• Organic & biomolecular chemistry

  Organic & biomolecular chemistry 10 (30), 5720-5731, 2012-03-19

  Royal Society of Chemistry

Keywords

• Amino Acid Sequence
• Animals
• Chemokine CXCL12/chemistry
• Ligands
• Molecular Imaging
• Molecular Sequence Data
• Peptides/chemistry
• Peptides/metabolism
• Peptides/pharmacology
• Peptidomimetics/chemistry
• Peptidomimetics/metabolism
• Peptidomimetics/pharmacology
• Receptors, CXCR4/antagonists & inhibitors
• Receptors, CXCR4/chemistry
• Receptors, CXCR4/metabolism

Details

• CRID: 1050845760697223936
• NII Article ID: 120005243444
• NII Book ID: AA1168650X
• ISSN: 14770520
• HANDLE: 2433/172240
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles