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Abstract

Electron transfer in DNA has been intensively studied to elucidate its biological roles and for applications in bottom-up DNA nanotechnology. Recently, mechanisms of electron transfer to DNA have been investigated; however, most of the systems designed are intramolecular. Here, we synthesized pyrene-conjugated pyrrole-imidazole polyamides (PPIs) to achieve sequence-specific electron injection into DNA in an intermolecular fashion. Electron injection from PPIs into DNA was detected using 5-bromouracil as an electron acceptor. Twelve different 5-bromouracil-containing oligomers were synthesized to examine the electron-injection ability of PPI. Product analysis demonstrated that the electron transfer from PPIs was localized in a range of 8 bp from the binding site of the PPIs. These results demonstrate that PPIs can be a useful tool for sequence-specific electron injection.

Journal

  • Nucleic acids research

    Nucleic acids research 41(8), 4724-4728, 2013-04-01

    Oxford University Press.

Codes

  • NII Article ID (NAID)
    120005245128
  • NII NACSIS-CAT ID (NCID)
    AA00760269
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0305-1048
  • Data Source
    IR 
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