Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection

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Abstract

IL28B single nucleotide polymorphisms (SNPs) are associated with spontaneous and treatment-induced elimination of hepatitis C virus (HCV). To assess whether the IL28B rs8099917 SNP also affects the progression of chronic HCV infection, we genotyped 511 Japanese HCV patients, including 69 with hepatocellular carcinoma (HCC). The T/T genotype of rs8099917 was not associated with the development of HCC (p = 0.623), although stepwise logistic regression analysis showed that liver cirrhosis, age greater than 68 years, and serum albumin <4.2 mg/dl were associated with HCC onset. It appears that the IL28B SNP does not directly influence hepatocarcinogenesis in chronic HCV infection.

Journal

  • HUMAN IMMUNOLOGY

    HUMAN IMMUNOLOGY 73(3), 298-300, 2012-03

    ELSEVIER SCIENCE INC

Cited by:  1

Codes

  • NII Article ID (NAID)
    120005247537
  • NII NACSIS-CAT ID (NCID)
    AA00214087
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    0198-8859
  • Data Source
    CJPref  IR 
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